暴露交叉设计

暴露交叉设计（exposure-crossover design）是由Donald A. Redelmeier在Journal of Clinical Epidemiology 66 (2013) 955-963中的一篇题为“The exposure-crossover design is a new method for studying sustained changes in recurrent events”论文中首次提出的一种新的流行病学研究设计，主要用于研究某一暴露是否与某一重复事件的发生相关。 公卫家园

The exposure-crossover design adopts the individual perspective to examine whether a specific exposure changed a person’s risks of a recurrent outcome. The exposure can be a medication, procedure, or other intervention with a documented start date and somewhat ongoing effects. The outcome can be any event, that is, recurrent, relapsing, or otherwise repeated with a documented time for each occurrence. ... the analysis would evaluate whether patient outcome rates are different before and after the exposure. 公卫论坛

The intent of the design is to test for a potential link between exposure and outcome. The name is selected to convey a notion that each patient serves as their own control and undergoes observation during a time with an exposure and a time without an exposure.

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参考文献 公卫论坛

Redelmeier, Donald A. "The exposure-crossover design is a new method for studying sustained changes in recurrent events." Journal of clinical epidemiology (2013). 公卫考场