余运贤

 余运贤，男，博士，浙江大学公共卫生学院流行病与卫生统计学系副教授，博士生导师。

公卫家园

 主要的学习和工作简历如下：1994年7月毕业于福建中医学院中西医结合临床专业；同年分配于福建省南平造纸厂医院从事临床内科工作；1996年9月-1999年7月就读于福建中医学院中西医结合临床硕士；1999年8月-2001年2月工作于福建省人民医院内经内科；2001年2月-2005年1月就读于中国科学技术大学生命科学学院攻读遗传学博士学位；2005年3月-2009年9月于哈弗大学公共卫生学院群体遗传学实验室进行博士后研究工作；2009年10月-2008年6月于美国西北大学儿童医院进行博士后研究工作；2008年8月- 于浙江大学公共卫生学院工作； 公卫家园

主要的研究兴趣：慢性复杂性疾病的遗传流行病学研究，包括低出生体重和早产、高血压、糖尿病、代谢综合症和结直肠癌，等。主要是从事人群遗传流行病学研究，通过分析遗传因素、环境因素，及其交互作用对疾病的发生发展的影响，从而阐明疾病的发病机制，为疾病的预防和控制提供基础理论数据。参与过多项NIH的研究课题，包括低出生体重和早产的遗传学研究、儿童食物过敏的遗传流行病学研究、高血压药物基因组学研究，等。以第一作者和共同作者身份发表20多篇SCI论文。 公卫人

科研项目：
1、承担浙江省教育厅资助的《结肠直肠癌的Caspase凋亡通路基因mRNA表达》项目编号Z200804565；
2、参与国家科技支撑计划项目《代谢综合征的早期识别和干预技术研究》项目编号：2009BAI80B00；
3、承担浙江省自然基金项目《REST通路相关基因多态性与结直肠癌遗传易感性的研究》项目编号：Y2090154； 公卫家园
4、承担教育部新教师基金项目《Tachykinin 1通路相关基因多态性与结直肠癌遗传易感性的研究》项目编号：20090101120103；
5、承担浙江大学青年科研创新专项经费《花生四烯酸代谢通路基因对人群结直肠癌的影响》项目编号：2009QNA7018；


发表的学术论文： 公卫百科
1. Yu Y, Venners SA, Wang B, Brickman WJ, Zimmerman D, Li Z, Wang L, Liu X, Tang G, Xing H, Xu X, Wang X. Association of central adiposity with prediabetes and decreased insulin sensitivity in rural Chinese normal-weight and overweight women. Metabolism. 2010 Jul;59(7):1047-53.

2. Yu Y., Tsai H. J., Liu X., Mestan K., Zhang S., Pearson C., Ortiz K., Xu X., Zuckerman B. & Wang X. The joint association between F5 gene polymorphisms and maternal smoking during pregnancy on preterm delivery. Hum Genet 2009.124: 659-68.
3. Yu. Y, Lu. BS, Wang. B, Wang. H, Yang. J, Li. Z, Wang. L, Liu. X, Tang. G, Xing. H, Xu. X, Zee. PC, Wang X. Short Sleep Duration and Adiposity in Chinese Adolescents. SLEEP 2007, 30
4. Yu Y, Kumar R, Venners S, Pongracic J, Wang B, Yang J, Li Z, Wang L, Liu X, Tang G, Xing H, Xu X, Wang X. Age and gender specific lung function predictive equations provide similar predictions for both a twin population and a general population from age 6 through adolescence. Pediatr Pulmonol 2007, 42:631-639

公卫考场

5. Yu Y, Niu T, Venners SA, Zhang Y, Chen C, Huang A, Feng Y, Li D, Xing H, Wu D, Peng S, Xu X. Associations of baseline blood pressure levels and efficacy of Benazepril treatment with interaction of alpha-adducin and ACE gene polymorphisms in hypertensives. Clin Exp Hypertens 2005, 27:83-94

公卫家园

6. Yu YX, Venners SA, Niu TH, Chen CZ, Huang AQ, Zhang Y, Feng Y, Li D, Xing HX, Wu D, Peng SJ, Xu XP. Significant associations of the alpha-adducin gene Gly460Trp polymorphism with serum bilirubin concentrations in Chinese essential hypertension patients. Yi Chuan Xue Bao 2004, 31:941-949 公卫百科
7. Mestan K, Yu Y, Thorsen P, Skogstrand K, Matoba N, Liu X, Kumar R, Hougaard DM, Gupta M, Pearson C, Ortiz K, Bauchner H, Wang X.Cord blood biomarkers of the fetal inflammatory response. J Matern Fetal Neonatal Med. 2009 May;22(5):379-87.
8. Tsai HJ, Yu Y, Zhang S, Pearson C, Ortiz K, Xu X, Bauchner H, Zuckerman B, Wang X. Association of genetic ancestry with preterm delivery and related traits among African American mothers. Am J Obstet Gynecol. 2009 Jul;201(1):94.e1-10. 公卫人
9. Zhang S, Liu X, Yu Y, Hong X, Christoffel KK, Wang B, Tsai HJ, Li Z, Liu X, Tang G, Xing H, Brickman WJ, Zimmerman D, Xu X, Wang X. Genetic and environmental contributions to phenotypic components of metabolic syndrome: a population-based twin study. Obesity (Silver Spring). 2009 Aug;17(8):1581-7. 公卫论坛
10. Matoba N, Yu Y, Mestan K, Pearson C, Ortiz K, Porta N, Thorsen P, Skogstrand K, Hougaard DM, Zuckerman B, Wang X. Differential patterns of 27 cord blood immune biomarkers across gestational age. Pediatrics. 2009 May;123(5):1320-8.
11. Mestan K, Yu Y, Matoba N, Cerda S, Demmin B, Pearson C, Ortiz K, Wang X. Placental inflammatory response is associated with poor neonatal growth: preterm birth cohort study.Pediatrics. 2010 Apr;125(4):e891-8. 公卫考场
12. Jiang S, Yu Y, Venners SA, Zhang Y, Xing H, Wang X, Xu X. Effects of MTHFR and MS gene polymorphisms on baseline blood pressure and Benazepril effectiveness in Chinese hypertensive patients.J Hum Hypertens. 2010 May 6. [Epub ahead of print]
13. Tsai HJ, Yu Y, Zhang S, Pearson C, Ortiz K, Xu X, Bauchner H, Zuckerman B, Wang X. Association of genetic ancestry with preterm delivery and related traits among African American mothers.Am J Obstet Gynecol. 2009 Jul;201(1):94.e1-10. 公卫论坛
14. Tsai H. J., Kumar R., Pongracic J., Liu X., Story R., Yu Y., Caruso D., Costello J., Schroeder A., Fang Y., Demirtas H., Meyer K. E., O'Gorman M. R. & Wang X. Familial aggregation of food allergy and sensitization to food allergens: a family-based study. Clin Exp Allergy 2009.39: 101-9.
15. Tsai HJ, Liu X, Mestan K, Yu Y, Zhang S, Fang Y, Pearson C, Ortiz K, Zuckerman B, Bauchner H, Cerda S, Stubblefield PG, Xu X, Wang X. Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways. Hum Genet. 2008 May;123(4):359-69.
16. Peng S, Yu Y, Hao K, Xing H, Li D, Chen C, Huang A, Hong X, Feng Y, Zhang Y, Li J, Wang B, Wu D, Wang X, Xu X. Heart rate-corrected QT interval duration is significantly associated with blood pressure in Chinese hypertensives. J Electrocardiol 2006, 39:206-210

公卫考场

17. Hong X, Xing H, Yu Y, Wen Y, Zhang Y, Zhang S, Tang G, Xu X. Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS. Methods Find Exp Clin Pharmacol 2007, 29:3-10
18. Chen G, Jiang S, Mao G, Zhang S, Hong X, Tang G, Li Z, Liu X, Zhang Y, Xing H, Wang B, Yu Y, Xu X. CYP2C9 Ile359Leu polymorphism, plasma irbesartan concentration and acute blood pressure reductions in response to irbesartan treatment in Chinese hypertensive patients. Methods Find Exp Clin Pharmacol 2006, 28:19-24 公卫人
19. Hong X, Zhang S, Mao G, Jiang S, Zhang Y, Yu Y, Tang G, Xing H, Xu X. CYP2C9*3 allelic variant is associated with metabolism of irbesartan in Chinese population. Eur J Clin Pharmacol 2005, 61:627-634
20. Zhang S, Mao G, Zhang Y, Tang G, Wen Y, Hong X, Jiang S, Yu Y, Xu X. Association between human atrial natriuretic peptide Val7Met polymorphism and baseline blood pressure, plasma trough irbesartan concentrations, and the antihypertensive efficacy of irbesartan in rural Chinese patients with essential hypertension. Clin Ther 2005, 27:1774-1784
21. Huang G, Xing H, Hao K, Peng S, Wu D, Guang W, Huang A, Hong X, Wang Y, Feng Y, Zhang Y, Li J, Chen C, Wang B, Zhang X, Li D, Yu Y, Liu J, Zhu G, Huo Y, Chen D, Hou Y, Wang X, Xu X, Niu T, Xu X. Beta2 adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese. Clin Exp Hypertens 2004, 26:581-592 公卫家园
22. Li D, Xing H, Hao K, Peng S, Wu D, Guang W, Huang A, Wang Y, Zhang Y, Yu Y, Li J, Chen C, Wang B, Zhu G, Huo Y, Chen D, Ronnenberg A, Niu T, Xu X. Hypertensive patients from two rural Chinese counties respond differently to benazepril: the Anhui Hypertension Health Care Study. Ann Epidemiol 2004, 14:123-128
23. 余运贤, 庞明, 陈甦, 梁晖. 小剂量尿激酶治疗脑血栓的临床观察 中国煤炭工业医学杂志 2001, 4:242
24. 江承设, 栋 李, 余运贤, 彭少杰, 李建平, 黄爱群, 徐希平. ET-1 Lys198Asn和eNOS Glu298Asp基因多态性与原发性高血压及硝苯地平降压疗效的相关性. 中国药理学通报 2003, 19:875-879

公卫论坛

25. 余运贤., 晖. 梁, 健. 黄, 等. 急性脑梗塞血瘀与一氧化氮、内皮素相关性研究. 中国中西医结合杂志 2000, 20:501-503
26. 梁晖, 余运贤, 等. 丹参注射液对脑梗塞急性期NO、ET的影响. 浙江中西医结合杂志 2000, 10:579-580