杨丽丽
Email：yangll7@mail.sysu.edu.cn
研究方向：酒精性和非酒精性脂肪肝、肝纤维化的发病机制及营养防治； 营养因素在肝癌治疗中作用； 营养与糖尿病防治； 功能性食品的的人群和实验室研究；
1. 教育背景
1992-1997 本科 哈尔滨医科大学预防医学系
1997-2000 硕士 中山医科大学营养系
2002-2006 博士 美国Case Western Reserve University School of Medicine
（凯斯西储大学）营养系
2.工作经历
2000-2002 讲师 中山医科大学公共卫生学院；
2006-2009 博士后 美国克利夫兰临床中心；
2010-2011 博士后/讲师 美国西奈山医学中心；
2011-2013 讲师 美国康奈尔大学医学院；
2013.04至今 教授 中山大学公共卫生学院
社会兼职
广东省脑卒中与预防康复学会常务理事；广东省营养学会理事；美国色谱质谱学会会员；美国自由基医学会会员；担任J of Hepatology; Liver International; Fundamental & Clinical Pharmacology; Free Radical Biology & Medicine; J of Nutrition; Nutrition Research; Alcohol; Alcohol and Alcoholism等期刊的审稿人。
主要承担或参与的课题
1. 国家自然科学基金面上项目，2019/01-2022/12，课题负责人；
2. 国家自然科学基金面上项目，2016/01-2019/12，课题负责人；
3. 国家自然科学基金面上项目，2014/01-2017/12，课题负责人；
4. 广东省特支计划青年拔尖人才资助计划，2017/10-2020/10，课题负责人;
5. 广东省自然科学基金面上项目，2015/09-2017/12，课题负责人；
6. 广东省科技厅协同创新重大项目，2016/09-2018/09，主要参与人;
7. 教育部回国人员启动基金， 2015/03-2016/03，课题负责人；
8. 中山大学重大培育项目， 2016/01-2017/12，课题负责人
9. 中山大学百人计划引进人才项目， 2013-2015，课题负责人
近期发表的主要文章 (* 通讯作者)
1．Wang, S., Wan, T., Ye, M., Qiu, Y., Pei, L., Jiang, R., Pang, N., Huang, Y., Liang, B., Ling, W., Lin, X*., Zhang, Z*., Yang, L*. Nicotinamide Riboside Attenuates Alcohol induced Liver Injuries via Activation of SirT1/PGC-1α/Mitochondrial Biosynthesis Pathway. Redox Biol. 2018. https:// doi.org/10.1016/j.redox. 2018. 04. 006.
2．Pei, L., Wan,T., Wang, S., Ye, M., Qiu, Y., Jiang,R., Pang, N., Huang, Y., Zhou, Y., Jiang,X., Ling, W., Zhang,Z., Yang,L.*. Cyanidin-3-O-β-glucoside regulates the activation and the secretion of adipokines from brown adipose tissue and alleviates diet induced fatty liver. Biomedicine & Pharmacotherapy. 2018, in press.
3． Qiu, Y., Wang, S., Wan, T., Ye, M., Jiang, R., Pei, L., Yang, L*. Blod-based novel biomarkers for nonalcoholic steatohepatitis. Biomarkers in Medicine. 2018. In press.
4. Qiu, Y., Wang, S., Yu, C., Chen, Q., Jiang, R., Pei, L., Huang, Y., Pang, N., Zhang, Z*., Ling, W*., Yang, L*. Association of Circulating Adipsin, Visfatin and Adiponectin with Nonalcoholic Fatty Liver Disease in Adults: A Case-Control Study. Annals of Nutrition and Metabolism. 2018. In press.
5. Ye，M., Wan, T., Pang, N., Wei, T., Huang, Y., Jiang, X., Zhang, Z* , Yang, L*., Oxidized Vitamin C (DHA) Overcomes Resistance to EGFR-targeted Therapy of Lung Cancer through Disturbing Energy Homeostasis. J of Cancer. 2018. In press.
6. Wan，T., Wang，S., Ye,M., .Ling, W. and Yang, L*. Cyanidin-3-O-β-glucoside protects against liver fibrosis induced by alcohol via regulating energy homeostasis and AMPK/autophagy signaling pathway. J of Funct. Food. 2017；37：16-24.
7. Chen, M., Liu, J., Yang, L*., Ling, W*. AMP-activated protein kinase regulates lipid metabolism and the fibrotic phenotype of hepaticstellate cells through inhibition of autophagy. FEBS Open Bio. 2017；7：811-820.
8. Yang, LP., Ling, W., Du, Z., Chen, Y., Li, D., Deng, S., Liu,Z*., Yang, L*. Effects of anthocyanins on cardiometabolic health: a systematic reviewand meta-analysis of randomized controlled trials. Advances in Nutrition. 2017：8(5)；684-693.
9 . Ye, M., Wang, S., Wan,T., Jiang,R.,Qiu, Y., Pei, L., Pang,N., Huang, Y., Huang, Y., Zhang, Z*., Yang, L*. Combined Inhibitions of Glycolysis and AKT/autophagy Can Overcome Resistance to EGFR-targeted Therapy of Lung Cancer. J of Cancer. 2017 ；8：3774-3784.
10. Yang， LP., Ling, W., Yang, Y., Chen, Y., Tian, Z., Du, Z., Chen, J., Xie, Y., Liu, Z*., Yang, L*. Role of putified anthocyanins in improving cardiometabolic risk factors in Chineses Men and Women with prediabetes or early untreated diabetes- a randomized controlled trial. Nutrients. 2017;9:1104-1118.
11. Yang, L*., Rozenfeld R., Wu, D., Devi, LA., Zhang, Z.*, and Cederbaum A*. Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free Radical Biology & Medicine. 68: 260-267, 2014.
12. Yang, L., Wu, D., and Cederbaum, AI*. CYP2E1, oxidative stress and MAPK signaling pathway in alcohol-induced hepatotoxicyt. (Review). J of Biochem and Pharm Res.2(2):74-90, 2014 .
13．Yang, L.*, Wu, D., Wang, X., and Cederbaum, AI*. Interactions between CYP2E1, JNK, Autophagy and oxidative stress in acute alcohol-induced fatty liver. Free Radical Biology & Medicine. 53; 1170-1180, 2012.
14．Yang, L*., and Cederbaum, AI. Interaction of CYP2E1 and anti-oxidative stress factors in alcoholic liver disease. Recent Advances in Alcoholic Liver Disease, 27-45 ISBN: 978-81-7895-571-1, 2012.
15．Yang, L., Wu, D., Wand, X., and Cederbaum, AI*.. Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1 induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells. Free Radical Biology & Medicine. 2011; 51: 185-196.
16. Yang, L., and Cederbaum, AI*.. CYP2E1, oxidative stress and MAPK signaling pathway in alcoholic liver disease (review). Research Trends- Current Topics in Toxicology. 2011(7): 1-11.
17. Yang, L., Latchoumycandane, C, McMulllen, M.R., Pratt, B.T., Zhang, R., Papouchado, B.G., Nagy, L.E., Feldstein, A.E., and McIntyre TM*.. Chronic alcohol exposure increases circulating bioactive oxidized phospholipids. J. Biol. Chem. 2010; 285(29):22211-20.
18．Yang L., Kombu RS, Kasumov T, Zhu SH, Cendrouski AV, David F, Anderson VE, Kelleher JK, Brunengraber H. Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: I. Interrelation between gluconeogenesis and catapleorosis: Formation of methoxamates from aminooxyacetate and ketoacids. J. Biol. Chem. 2008; 283(32): 21978-21987.
19．Yang L., Kasumov T, Kombu RS, Zhu SH, Cendrouski AV, David F, Anderson VE, Kelleher JK, Brunengraber H. Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: II. Heterogeneity of metabolite labeling pattern. J. Biol. Chem. 2008; 283(32): 21988-21996.
20. Yang L., Kasumov T, Lynn Yu, Jobbins KA, David F, Kelleher JK, Previs SF, Joanne, K. Kelleher and Brunengraber H. Metabolomic assays of the concentration and mass isotopomer distributions of gluconeogenic and citric acid cycle intermediates. Metabolomics. 2006; 2(2): 85-94.
21. Ismailoglu, I., Chen, Q., Popowski, M., Yang, L., Gross, S.S. *, and Brivanlou, AH*. Huntingtin protein is essential for mitochondrial metabolism bioenergetics and structure in murine embryonic stem cells. Developmental Biology. 2014; 391: 230-240.
22．Wang, X., Wu D., Yang, L., Gan, L., Cederbaum, AI*. CYP2E1 Potentiates Ethanol-induction of Hypoxia and HIF-1α in vivo. Free Radical Biology & Medicine. 63:175-186, 2013.
23．Wu, D., Wang, X., Yang, L., and Cederbaum, AI*. Role of Autophagy in the Modulation of Cytochrome P4502E1-mediated Binge Alcohol Liver Steatosis and Cytotoxicity. Free Radical Biology & Medicine. 53(6): 1346-57, 2012.
24．Cederbaum, AI*, Yang, L., Wang, X, Wu, D. CYP2E1 sensitizes the liver to LPS and TNF-induced toxicity via elevated oxidative and nitrosative stress and activation of ASK-1 and JNK mitogen activated kiniases. International J of Hepatology. 2012; 2012: 582790.
25. Wang, X., Wu, D., Yang, L., Cederbaum, AI*. Hepatotoxicity mediated induced by TNFα was mediated by JNK1 but not JNK2. Hepatology. 2011. 54(5):1753-66.
26. Chen J., Yang L., Foulks JM, Weyrich AS, Marathe GK, McIntyre TM. Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. J Lipid Res. 2007; 48(11):2365-76.
27．Chen R., Yang L., and McIntyre TM. Cytotoxic phospholipid oxidation products: cell death from mitochondrial damage and the intrinsic caspase cascade. J. Biol. Chem. 2007; 282(34):24842-50.
28．王素凡，杨丽丽*.酒精性肝病的机制及研究进展. 国际肝病. 2013; 10-12-13.
29．万婷，杨丽丽*. 花色苷对酒精性肝病的防治及机制. 华南预防医学. 2017；43（2）： 187-191.
30．杨丽丽，凌文华，马静，唐志红，吴聪娥。溶血卵磷脂对巨噬泡沫细胞胆固醇外流的影响。中国病理生理杂志， 2001; 18 (1): 28-31.
31．杨丽丽, 凌文华, 马静, 唐志红。钙离子信使通路在溶血卵磷脂促进巨噬泡沫细胞胆固醇。中国动脉硬化杂志，2001; 9 (3): 190-193.
32．杨丽丽，凌文华。氧化型低密度脂蛋白与动脉粥样硬化（综述）。国外医学内科学分册，2000; 27 (2): 58-61。
33. 丘云，王素凡，裴蕾，姜瑞，杨丽丽. 广州市成年人非酒精性脂肪肝的相关因素。热带医学杂志，2018,18（3）:279-284.
34. 姜瑞，王素凡，丘云，裴蕾，杨丽丽. 尼克酰胺核糖对C57BL/6J小鼠糖耐量、胰岛素抵抗的影响及其机制研究。热带医学杂志，2018（4）:18-22.
35. 裴蕾，万婷，王素凡，杨丽丽. 桑葚花色苷提取物对高脂酒精膳食作用下小鼠棕色脂肪组织改变的影响。热带医学杂志，2018(5)
参编书籍：
《Basic Nutrition and Diet Therapy》 编者
《肿瘤营养学》编者
《公共卫生学概论》编者
《中国公共卫生理论与实践》编者
研究生培养情况
现培养博士生1名，硕士生5名。
已经培养博士生2名，硕士生6名，MPH硕士2名, 本科生5名。
获奖情况
广东省特支计划青年拔尖人才
中山大学百人计划引进人才
中山大学公共卫生学院青年教师英文授课大赛第一名
中山大学青年教师英文授课大赛三等奖
连续两次指导中山大学公共卫生学院MPH 硕士优秀论文
招生专业
营养与食品卫生学
招生/招聘信息
招收博士后、专职科研人员、副研究员；
招收博士生、硕士生、本科生；
欢迎对代谢性疾病、脂肪肝、肝纤维化发病机制，以及相关营养防治的人群与实验室研究、肠道菌群、及生物标志物探讨感兴趣的本科生、硕士生、博士生、博士后及专职科研人员加入我们的大家庭。
