刘云岗

 

职 称：

教授 博导

通信地址：

南方医科大学公共卫生与热带医学学院毒理学系，广州510515

Email：

yungliu@fimmu.com

职 务：

南方医科大学毒理学系主任

职称级别：

正高

学术任职：

广东省细胞生物学学会常务理事; 广东省抗癌学会理事广东省环境诱变剂学会理事

最高学历：

博士

所属科室：

毒理学系

研究方向：

化学致突变物的代谢活化; 环境化合物与生物转化酶的相互作用

科研项目：

1. 作为项目负责人,目前主持广东省高等学校人才引进专项基金1项:多氯联苯与多环芳烃代谢活化与遗传毒性研究(2010.10-2013.09, 40万人民币) 公卫家园 2. 作为课题负责人，主持广东省自然科学基金面上项目1项（2012.10-2014.09）

成果奖励：

2006年广州市科委科技成果二等奖（镍化合物致癌的分子机制研究)

代表论文：

1. Hong Deng, Hai Gao, Yungang Liu*. Biotransformation enzyme-dependent formation of micronuclei and multinuclei in V79-hCYP2E1-hSULT1A1 cells by N-nitrosodimethylamine and 2-nitropropane. Mutation Research, 2011, 726(1):84-87. 公卫人 2. Edugie J. Ekuase, Yungang Liu, Hans-Joachim Lehmler, Larry W. Robertson, Michael W. Duffel. Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1. Chemical Research in Toxicology, 2011, 24(10):1720-1728. 公卫考场 3. Yungang Liu, Hans-joachim lehmler, Larry W. Robertson, Michael W. Duffel. Physicochemical properties of hydroxylated chlorinted biphenyls aid in predicting their interactions with rat sulfotransferase 1A1 (rSULT1A1). Chemico-Biological Interactions, 2011;189(3):153-160. 公卫论坛 4. Yungang Liu* and Hansruedi Glatt. Human SULT1A1 and CYP2E1 co-expressed in Chinese hamster V79 Cells enhance spontaneous mutagenesis. Environmental and Molecular Mutagenesis, 2010;51(1):23-30 5. Yungang Liu, Jason Smart, Yang Song, et al. Structure-activity relationships for hydroxylated polychlorinated biphenyls as substrates and inhibitors of rat sulfotransferases and modification of these relationships by changes in thiol status. Drug Metabolism and Disposition, 2009; 37(5):1065-1072 公卫人 6. Yungang Liu* and Hansruedi Glatt. Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes. Mutation Research, 2008;643(1-2):64-69. 7. Hayrettin Ozan Gulcan, Yungang Liu, Michael W. Duffel. Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1. Chemical Research in Toxicology, 2008;21(8):1503-1508. 公卫人 8. Yungang Liu, T. Idil Apak, Hans-Joachim Lehmler, et al. Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1. Chemical Research in Toxicology, 2006;19(11):1420-1425. 9. Hansruedi Glatt, Heiko Schneider, Yungang Liu. V79-hCYP2E1-hSULT1A1, a cell line for sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals. Mutation Research, 2005;580(1):41-52. 公卫考场 10. Ulricke Bernauer, Hansruedi Glatt, Barbara Heinrich-Hirsch, Yungang Liu, et al. Heterologous expression of mouse cytochrome P450 2e1 in V79 cells: Construction and characterisation of the cell line and comparison with V79 cell lines stably expressing rat P450 2E1 and human P450 2E1. Alternatives to Laboratory Animals, 2003;31(1):21-30 公卫家园 11. Yungang Liu, Eva Muckel, Johannes Doehmer, Hansruedi Glatt. Phenol and hydroquinone induce gene mutations in V79-derived cell lines expressing human xenobiotic-metabolizing enzymes. Nova Acta Leopoldina, 2003;87(329):231-237. 12. Yungang Liu*, Pingchang Zhang, Fei Yi. Asbestos fiber burdens in lung tissues of Hong Kong Chinese with and without lung cancer. Lung Cancer, 2001;32(2):113-116. 公卫家园 13. Fan Lin, Yungang Liu, Yuqing Liu, et al. Crocidolite induces cell transformation and p53 gene mutations in BALB/c-3T3 cells. Teratogenesis, Carcinogenesis, and Mutagenesis, 2000;20(5):273-281. 14. Jiakun Chen, Zhongliang Wu, Yungang Liu, et al. Effects of metabolites of benzo(a)pyrene on unschedule DNA synthesis in BALB/c-3T3 cell line. Chemosphere, 2000;41(1-2):139-142. 公卫家园 15. Yungang Liu*, Zhongliang Wu, Jiakun Chen. Differential effects of aneugens and clastogens on incidences of multinucleated cells and of micronucleate cells in Chinese hamster lung (V79) cell line in vitro. Mutation Research, 1998;413(1):39-45. 16. 刘云岗*，屠鸿薇，羟基多氯联苯与人和大鼠羟基固醇类硫酸基转移酶的相互作用，重庆医科大学学报，2011；36（7）：800-804. 公卫考场 17. 刘云岗*，胡克歧，酶抑制剂对V79-hCYP2E1-SULT1A1细胞酶依赖性化学诱变的影响，重庆医科大学学报，2011；36（9）：1029-1032. 18. 刘云岗*，姜浩，氧化型谷胱甘肽对大鼠硫酸基转移酶1A1与羟基多氯联苯作用的影响，重庆医科大学学报，2011；36（10）：印刷中.

公卫人

1

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