Wenjun Sun

1. Morphological studies using confocal microscopy and electron microscopy.

2. Primary trophoblasts culture and the analysis of hormone secretion of trophoblasts.

3. Study of cellular signal transduction pathways using Western blot technology.

4. Lipids analysis using HPLC and MS technology.

There exists the controversy with respect to whether exposure to extremely low frequency magnetic fields can produce adverse productive health effects. In the project, we investigated the effects of 50 Hz magnetic fields exposure on morphological structure and hormone secretion function using primary cultured human trophoblasts. The preliminary results showed that exposure to magnetic fields at high intensity for long time could significantly inhibit hormone secretion of progesterone and human chorionic gonadotrophin (hCG). However, magnetic fields did not affect the cellular ultramicrostructure and the expression of apoptosis-related genes. It indicated that magnetic fiends could inhibit the hormone secretion in an apoptosis independent manner.

It is well known that exposure to electromagnetic fields can cause some biological effects. However, the mechanisms are unclear so far. In our previous studies, we found electromagnetic fields could activate the cellular membrane receptor. In the project, we will investigate the signal transduction pathways related to receptor for clearing the signal transduction process of electromagnetic fields.

SUN Wenjun graduated from Zhejiang Medical University in 1994 and received Ph. D. from Zhejiang University in 2003. Since 1994, he has engaged in speciality of bioelectromagnetics and occupational hygiene, and mainly focused on study of mechanisms of biological effects induced by electromagnetic fields. He has worked in Lund University in Sweden as a visiting researcher for two years (2007-2008, 2009-2010). He has taken charge of more than eight foundations, including 4 NSFC, and published more than thirty papers.

1.Wenjun Sun*, Yaping Gan, Yiti Fu, Deqiang Lu and Huai Chiang. An Incoherent Magnetic Field Inhibited EGF Receptor Clustering and Phosphorylation Induced by a 50-Hz Magnetic Field in Cultured FL Cells. Cell Physiol Biochem., 2008, 22(5-6): 507-514

3.W.J.Sun*, Y.N.Yu, H.Chiang, Y.D.Fu, H.Y.Xie, and D.Q.Lu. Exposure to 50Hz Magnetic Fields Does not Induce the Phosphorylation of SEK1/MKK4 in Cultured Cells. Electromagn Biol Med., 2002, 21(1): 97-102

4.W.J.Sun*, H.Chiang, Y.D.Fu, Y.N.Yu, H.Y.Xie, and D.Q.Lu. Exposure to 50Hz Electromagnetic Fields Induces the Phosphorylation and Activity of Stress-activated Protein Kinase in Cultured Cells. Electro Magneto Biol., 2001, 20(3)415-423

5.W.J.Sun*, Y.N.Yu,H.Chiang,Y.D.F,and D.Q.Lu. Effects of 50Hz Magnetic Fields Exposure on Protein Tyrosine Phosphorylation in Cultured Cell. Electro Magneto Biol., 2001, 20(2)207-214