陈虹

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陈虹研究员 硕士生导师

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公卫人

研究方向与目前进展

近年来主要从事基因工程药物及蛋白质相互作用的研究，如：靶向性抗肿瘤融合蛋白、重组人IFN-l1和神经生长因子等的表达及生物学活性的研究；可通过血脑屏障模拟多肽的筛选；生长因子及其受体相互作用及信号传导的研究等，已发表论文综述几十余篇，申请发明专利3项，其中1项已获专利证书，曾获北京市科技进步奖2次。 公卫人

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主要学习及工作简历 公卫人

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代表性学术论文 公卫考场

1. Zhou Y, Chen H, Ma XL, Xie HJ, Wang CL, Zhang SH, Wang X, Huang BR. Fusion protein of adenovirus E4orf4 and human epidermal growth factor inhibits tumor cell growth. Int J Cancer. 2009; 125(5):1186-92. 公卫家园

2. Wang CL, Chen H, Ma XL, Wang X, Huang BR. Trafficking pathway and affectivity on extracellular signal-regulated kinase phosphorylation of anti-tumor fusion protein of epidermal growth factor-adenovirus early region 4 open reading frame 4 protein. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009; 31(6):674-8. Chinese. 公卫论坛

3. Wang DM, Zhou Y,Xie HJ, Ma XL, Wang X, Chen H, Huang BR. Cytotoxicity of a recombinant fusion protein of adenovirus early region 4 open reading frame 4 (E4orf4) and human epidermal growth factor on p53-deficient tumor cells. Anticancer Drugs. 2006; 17(5):527-37.

4. Xie Yun-Fei, Chen Hong, Huang Bing-Ren: Expression, purification and characterization of human IFN-<lambda>1 in Pichia pastoris. Journal of Biotechnology. Journal of Biotechnology. 2007, 129(3):472-480.

5. Chen Zhao-Li, Chen Hong, Wang Xi, Ma Xiao-Li, Huang Bing-Ren: Expression, purification and characterization of secreted recombinant human insulin-like growth factor binding protein-6 in methylotrophic yeast Pichia pastoris. Protein expression and Purification. 2007，52：239-248. 公卫家园

6. Haibing Zhang1, Qu Zhang1, Liming Wang2, Hong Chen3, Yuqin Li4, Tianpen Cui5, Wei Huang6, Liangliang Zhang1, Fei Yan1, Lisa Wang1, Yiping Xu2, Landian Hu1*, and Xiangyin Kong1,7* Association of IL4R Gene Polymorphisms with Asthma in Chinese Populations. Hum Mutat. 2007; 28(10):1046

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7. Lonjou C, Barnes K, Chen H, et al. A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthmagenetics (COAG). Pric Natl Acad Sci USA ,2000, 97:10942-10947.

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8. Chen H., Griffin DK., et al Evaluating the culture of fetal erythroblast from maternal blood for non-invasive prenatal diagnosis Prenat Diagn 1998, 18:883-892

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重要奖项

公卫家园

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联系方式

    邮箱：hchen@public.bta.net.cn 公卫百科