韩代书

公卫百科

韩代书教授 博士生导师 公卫百科

  公卫人

研究方向 公卫考场

精子发生及红细胞分化的调控机理：（1）Toll-like 受体（TLR）在Sertoli细胞中的功能与调控：曲细精管为免疫豁免位点，我们发现Sertoli细胞表达多个TLR的成员，并证明它们在调节睾丸的天然免疫中起重要作用，进一步阐明了这一系统的调控机理。为认识曲细精管的免疫豁免特性的机理提供了新的证据。（2）TAM受体调节红细胞分化的功能：发现TAM受体表达于各分化阶段的红细胞中，TAM缺失导致红细胞分化异常，主要阻止在早期分化阶段，TAM通过调节EPO及其受体的表达发挥作用。为通过调节TAM信号通路治疗贫血病提供了新的线索。

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主要学习及工作简历 公卫人

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代表性学术论文

1． Bing Sun, Nan Qi, Tao Shang, Hui Wu, Tingting Deng, and Daishu Han. Sertoli cell-initiated testicular innate immune response through Toll-like receptor-3 activation is negatively regulated by Tyro3, Axl, and Mer Receptors. Endocrinology 2010, 151: 2886-28. 2． Yongmei Chen, Huizhen Wang, Nan Qi, Hui Wu, Weipeng Xiong, Jing Ma, Qingxian Lu, Daishu Han. Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice. Reproduction, 2009, 138:655-666.

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3． Hongmei Tang, Song Chen, Haikun Wang, Hui Wu, Qingxian Lu and Daishu Han. TAM receptors and the regulation of erythropoiesis in mice. Haematologica/The Hematology Journal, 2009, 94:326-334. 公卫人

4． Weipeng Xiong, Haikun Wang, Hui Wu, Yongmei Chen, Daishu Han. Apoptotic spermatogenic cells can be energy sources of Sertoli cells. Reproduction, 2009, 137:469-479. 公卫家园

5． Hui Wu, Hongmei Tang, Yongmei Chen, Haikun Wang, Daishu Han. High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamily. Mol Reprod Dev. 2008 75:1775-82. 公卫家园

6． Hui Wu, Haikun Wang, Weipeng Xiong, Song Chen, Hongmei Tang, Daishu Han. Expression patterns and functions of Toll-like receptors in mouse Sertoli cells. Endocrinology 2008 149: 4402-4412. 公卫家园

7． Weipeng Xiong, Yongmei Chen, Huizhen Wang, Haikun Wang, Jing Ma, Yehua Ge, Qingxian Lu, Shepu Xue, Daishu Han. Gas6 and Tyro 3 RTK subfamily regulate phagocytic function of Sertoli cells. Reproduction, 2008, 135:77-87.

8． Haikun Wang, Yongmei Chen, Song Chen, Huizhen Wang, Weipeng Xiong, Jing Ma, Yehua Ge, Qingxian Lu, Daishu Han. Tyro 3 subfamily receptors regulate hemostasis and megakaryocytopoiesis. Haematologica/The Hematology Journal, 2007, 92:643-650. 公卫家园

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联系方式 公卫论坛

     邮箱：dshan@ibms.pumc.edu.cn

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