许彩民

公卫百科

许彩民教授 博士生导师 公卫家园

  公卫家园

研究方向及目前进展

肿瘤细胞凋亡与信号转导及基因表达与调控 公卫论坛

 采用基因芯片和蛋白质组学分析，发现硒诱导白血病细胞凋亡的主要信号通路与线粒体和内质网有关。并发现了线粒体与内质网促凋亡的节点蛋白。同时也发现凋亡与自噬的转换关系对肿瘤细胞具有十分重要的意义。

公卫百科

主要学习及工作简历 公卫家园

  公卫论坛

  公卫家园

社会任职 公卫论坛

北京生化学会理事

代表性学术论文 公卫家园

1. Fang Huang YangYang, YunRen, CaiminXu* Quan Chen* Selenite induces redox dependent Bax activation and apoptosis in colorectal cancer cells. Free Radical Biology and Medcine 2009，2009;46;(8)1185-1195. 公卫人

2. Yingying zhu ;Daofeng Ni*;Caimin Xu* Gene expression profiles in the olfactory blulb from and rat model of Alzheimor’s disease。 Journal of Alzheimer’s Disease 2009；18（3）581-593

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3 . Liying Guan Binshe Zhushi Li Yang Yang Caimin Xu* . Sodium selenite induces apoptosis by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in human acute promyelocytic leukemia NB4 cells . Apoptosis. 2009 ;14(2):218-25.

4. Guan L, Han B, Li J, Li Z, Huang F, Yang Y, XuCaimin*. Exposure of human leukemia NB4 cells to increasing concentrations of selenite switches the signaling from pro-survival to pro-apoptosis. Ann Hematol. 2009;88(8):733-42. 公卫考场

5. Liying Guan , Qian Jiang , Zhushi Li , Yun Ren, Yang Yang Caimin Xu * Selenite induces apoptosis by mediating the release of MnSOD from mitochondria to cytosol in leukemia cells. BMB Reports 2009;30;42(6):361-6.

6 . Bingshe Han, Yun Ren, Liying Guan,Yang Yang and XuCaimin*.Sodium selenite induces apoptosis in acute promyelocytic leukemia-derived NB4 cells through mitochondria-dependent pathway. Oncology Research 2009;17(8):373-81. 公卫百科

7. Yang Yang,Lan Chen,Tao Yang,Bing-She Han, XuCaimin* Glycosylation Modification of Human Prion Protein Provokes Apoptosis in HeLa Cells in vitro BMB repotr 2009;vol42;331-337.

公卫家园

8. Yang Yang, Fang Huang, Yun Ren, Lu Xing, Ying Wu, Huazhen Pan,and XuCaimin*.The anticancer effects of sodium selenite and selenomethionine on human colorectal carcinoma cell lines in nude mice. Oncology Research 2009;18(1):1-8.9. 公卫人

9. Liying Guan ,Huang fang,Lizhu shi ,Qian jiang, Yang Yang Caimin Xu* P53 transcription indepent activity mediates sodium selenite-induced acute promyelocytic leukemia NB4 cells apoptosis BMB Reports 2008;31;4(10):745-50

公卫考场

10.Han B, Wei W, Hua F, Cao T, Dong H, Yang T, Yang Y, Pan H, Xu Caimin * Requirement for ERK activity in sodium selenite-induced apoptosis of acute promyelocytic leukemia-derived NB4 cells. J Biochem Mol Biol. 2007 ；31;40(2):196-204 公卫百科

11. Chen L, Yang Y, Han J, Zhang BY, Xu CM* Removal of the glycosylation of prion protein provokes apoptosis in SF126 J Biochem Mol Biol. 2007 ； 30;40(5):662-9 公卫论坛

12. Hua Dong，Caimin Xu* comparative proteomic analysis of apoptosis induced by sodium selenite in human acute promyelocytic leukemia NB4 cells J. Cellular Biochem. 2006；98；（6）1495-1506

13. Ting min Cao; Caimin Xu*, An analysis of the different effects that defferent concentrations of selenium have on NB4 cells and identification of differentially expressed genes after sodium selenite treatment via cDNA microarray Annalysis of Hematolgy 2006；85；434－442 公卫百科

14. Yang Yang, Jian Wang, Caimin Xu* Maltol Inhibits Apoptosis of Human Neuroblastoma Cells Induced by Hydrogen Peroxide Journal of Biochemistry and Molecular Biology 2006；39（2）145-150 公卫论坛

15.Cailing Lu;Fei chan Qiu; Haijun Zhou; Caimin Xu* ，Xiaozhong peng* Identificationg and characterization of selenoprotein K; An antioxidant in cardiomyocytes FEBS Letters 2006;580;(22)5189-519749

公卫家园

16. Bingshe Han,Ren Yun, Liying Guan , Yang Yang Caimin Xu* Sodium selenite-induced in acute promyelocytic leukemia NB4 cells Through mitochondria-dependent pathway Oncology Research 2008 in press 11.Han B, Wei W, Hua F, Cao T, Dong H, Yang T, Yang Y, Pan H, Xu C* Requirement for ERK activity in sodium selenite-induced apoptosis of acute promyelocytic leukemia-derived NB4 cells. J Biochem Mol Biol. 2007 ；31;40(2):196-204 17. Removal of the glycosylation of prion protein provokes apoptosis in SF126 Chen L, Yang Y, Han J, Zhang BY, Xu CM* J Biochem Mol Biol. 2007 ； 30;40(5):662-9 公卫百科

18.Hua Dong，Caimin Xu* comparative proteomic analysis of apoptosis induced by sodium selenite in human acute promyelocytic leukemia NB4 cells J. Cellular Biochem. 2006；98；（6）1495-1506 公卫论坛

19. Ting min Cao; Cai min Xu*, An analysis of the different effects that defferent concentrations of selenium have on NB4 cells and identification of differentially expressed genes after sodium selenite treatment via cDNA microarray Annalysis of Hematolgy 2006；85；434－442

公卫考场

20. Yang Yang, Jian Wang, Caimin Xu* Maltol Inhibits Apoptosis of Human Neuroblastoma Cells Induced by Hydrogen Peroxide Journal of Biochemistry and Molecular Biology 2006；39（2）145-150 16.

公卫人

21.Cailing Lu;Fei chan Qiu; Haijun Zhou; Caimin Xu* ，Xiaozhong peng* Identificationg and characterization of selenoprotein K; An antioxidant in cardiomyocytes FEBS Letters 2006;580;(22)5189-519749 公卫人

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重要奖项

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联系方式 公卫百科

    邮箱：caiminxu@yahoo.com.cn 公卫人