SCCS

What is the self-controlled case series method?
The self-controlled case series (SCCS) method is an alternative study method for investigating the association between a transient exposure and an adverse event. The method was developed to study adverse reactions to vaccines. The method uses only cases, no separate controls are required as the cases act as their own controls. Each case's given observation time is divided into control and risk periods. Time-varying confounding factors such as age can be allowed for by dividing up the observation period further into age categories. An advantage of the method is that confounding factors that do not vary with time, such as genetics, location, socio-economic status are controlled for implicitly.

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